comparison of epstein barr virus antibodies and tcell cytokines production in patients with multiple sclerosis and healthy individuals
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abstract
abstract background: multiple sclerosis (ms) is the most common autoimmune disease of central nervous system with destruction of myelin sheath mediated by auto reactive cd4+ t lymphocytes. because of the possible role of epstein-barr virus in etiology of ms and t cells immune response, the aim of this study was to evaluate anti-epstein barr virus antibodies as a marker of reactivity and production of th1 and th2 cytokines in ms patients and healthy individuals. methods: blood samples were taken from 68 ms patients at different stages of diseases and 20 apparently healthy individuals and plasma levels of anti- ebv nuclear antigen-1 (ebna-1) and viral capsid antigen (vca) antibodies determined and concentrations of ifn- [1] , il-12 and il-4 in culture supernatants of pha-activated peripheral blood mononuclear cells (pbmc) were measured by elisa. results: the mean levels of anti ebna-1 and vcaantibodies were significantly higher in patients compared to controls (p=0.04, p=0.001 respectively). concentrations of ifn- [1] , il-4 & il-12 were also significantly higher in ms patients than healthy individuals (p=0.001, p=0.005, p=0.002, respectively). significant correlation was found between anti ebna-1 and vcaantibodies and il-12 production (p =0.02, r=0.27& p=0.04, r=0.25, respectively) whereas no significant correlation was found between these antibodies and production of ifn- [1] or il-4. conclusions: due to elevated level of anti-ebv antibodies and t cell cytokines in ms patients rather than healthy individuals, epstein barr virus may play role in etiology of ms disease through activation of t cells immune response.
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Abstract Background: Multiple sclerosis (MS) is the most common autoimmune disease of central nervous system with destruction of myelin sheath mediated by auto reactive CD4+ T Lymphocytes. Because of the possible role of Epstein-Barr virus in etiology of MS and T cells immune response, the aim of this study was to evaluate anti-Epstein Barr virus antibodies as a marker of reactivity and p...
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چکیده ندارد.
Multiple sclerosis and Epstein-Barr virus.
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Epstein-Barr virus (EBV) is one of the most common and successful human viruses, infecting more than 90% of the world's adult population. Despite its strong tumorigenic potential, most virus carriers remain healthy due to maintenance of a delicate balance between the host's immune system, which limits production of virus particles, and the virus, which persists for the duration of the host's li...
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Journal title:
medical journal of islamic republic of iranجلد ۲۴، شماره ۳، صفحات ۱۱۵-۱۲۵
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